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A DOTS-Plus Handbook
Guide to the Community-Based Treatment of MDR TB
Partners In Health
Harvard Medical School
Bill and Melinda Gates Foundation
Forms of tuberculosis untreatable with first-line drugs pose challenges
quite unlike those posed by other resistant pathogens: an airborne bacterium,
Mycobacterium tuberculosis is already a leading infectious cause of adult
deaths in the world. In communities where MDR TB is already a public-health
emergency,much can be done to turn the tide.
Effective therapy-based programs — “DOTS-Plus”
— are an essential part of a humane response
to suffering and will contain further spread. A DOTS-Plus Handbook: Guide
to the Community-Based Treatment of MDR TB describes the approach taken
by a transnational consortium of health workers constituted to respond
to the problem of MDR TB in rural Haiti and urban Peru.This Handbook describes
the technical framework and principles used to implement DOTS-Plus in resourcepoor
settings. It also provides a number of case histories that illustrate common
challenges in the treatment of MDR TB patients. Finally, the Handbook includes
protocols that can be used under DOTS-Plus program conditions to manage
common complication of this therapy. The principles outlined will be adaptable
to other settings where DOTS-Plus interventions are necessary.
© Partners In Health, 2002
A DOTS-Plus Handbook
Guide to the Community-Based
Treatment of MDR TB
- Download the
full manual in English (17.6 MB, PDF)
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